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Is tacrolimus the same as cyclosporine? Tacrolimus and cyclosporine differ in their chemical structure: cyclosporine is a cyclic endecapeptide [8], whereas tacrolimus is a macrocyclic lactone [9]. However, they act in a similar manner. Both are calcineurin inhibitors; their main mechanism of action involves inhibition of this important phosphatase [1].
Can you open tacrolimus capsules? Tacrolimus should be given about the same time each day to keep a constant level in the blood. It should be taken about 12 hours apart and at least one hour before food, in two equal doses. The capsules can be swallowed whole or opened and diluted with water or orange juice.